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CAS No.: 65-19-0
Synonyms: 盐酸育亨宾;育酚;育亨宾盐酸盐
Yohimbine HCl is naturall occuring alpha-2 adrenergic antagonist derived from the bark of the African tree Pausinystalia johimbe, used as a veterinary drug to reverse sedation in dogs and deer.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00001329 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00748059 | Autonomic Nervous System Disea... more >>ses Orthostatic Hypotension Dopamine Beta-Hydroxylase Deficiency Orthostatic Intolerance Collapse << | Phase 1 | Active, not recruiting | December 2018 | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00223717 | Hypertension | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
实验方案
技术信息
CAS号 | 65-19-0 | 储存条件 |
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分子式 | C21H27ClN2O3 | 运输 | 蓝冰 | |||||||
分子量 | 390.90 | 别名 | 盐酸育亨宾;育酚;育亨宾盐酸盐;柯楠质盐酸盐;萝芙根 (皮) 碱盐酸盐;盐酸萝芙根 (皮) 碱 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00001329 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00748059 | Autonomic Nervous System Disea... more >>ses Orthostatic Hypotension Dopamine Beta-Hydroxylase Deficiency Orthostatic Intolerance Collapse << | Phase 1 | Active, not recruiting | December 2018 | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00223717 | Hypertension | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00004329 | - | - | Completed | - | United States, Texas ... more >> University of Texas Medical Branch Galveston, Texas, United States, 77555-0209 Collapse << |
NCT00684840 | - | - | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48202 Collapse << |
NCT03015246 | Heroin Dependence ... more >> Opioid Use Disorder Collapse << | Phase 1 | Recruiting | December 2020 | United States, Kansas ... more >> Vince and Associates Recruiting Overland Park, Kansas, United States, 66212 Contact: Debra Kelsh, M.D. 913-696-1601 ext 6160 dkelsh@altasciences.com Principal Investigator: Mark Greenwald, PhD Principal Investigator: Debra Kelsh, M.D. Collapse << |
NCT00109642 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00000195 | Opioid-Related Disorders | Phase 2 | Withdrawn | - | United States, Connecticut ... more >> VA Connecticut Healthcare System New Haven, Connecticut, United States, 06519 Collapse << |
NCT00223691 | Autonomic Failure ... more >> Orthostatic Hypotension Collapse << | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00103987 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00000196 | Opioid-Related Disorders | Phase 2 | Withdrawn | - | United States, Connecticut ... more >> VA Connecticut Healthcare System New Haven, Connecticut, United States, 06519 Collapse << |
NCT00709098 | Pulmonary Arterial Hypertensio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT02007694 | Phobic Disorders | Phase 2 Phase 3 | Completed | - | Netherlands ... more >> University of Amsterdam Amsterdam, Nord Holland, Netherlands, 1018XA Collapse << |
NCT03670212 | Cigarette Smoking | Phase 1 | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48201 Collapse << |
NCT00709956 | Pulmonary Arterial Hypertensio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT02243709 | Alcohol Use Disorders (AUD) | Phase 1 Phase 2 | Recruiting | December 2019 | United States, Rhode Island ... more >> Center for Alcohol and Addiction Studies, Brown University Recruiting Providence, Rhode Island, United States, 02912 Contact: Victoria Long, BS 401-863-6646 alcohol.stress.study@gmail.com Principal Investigator: Carolina L Haass-Koffler, PharmD Sub-Investigator: Robert M Swift, MD, PhD Collapse << |
NCT02541071 | Intrusive Memories | Not Applicable | Completed | - | Germany ... more >> Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Benjamin Franklin Berlin, Germany, 12203 Collapse << |
NCT00709956 | - | - | Completed | - | - |
NCT00029627 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00709098 | - | - | Completed | - | - |
NCT01621620 | Pain | Not Applicable | Unknown | August 2014 | Israel ... more >> Tel Aviv Sourasky Medical Center, Pain Medicine Unit Not yet recruiting Tel Aviv, Israel Contact: Lior Dayan, M.D 972-50-4051014 Collapse << |
NCT02470026 | Major Depressive Disorder ... more >> Early Life Trauma Collapse << | Not Applicable | Recruiting | October 2018 | Germany ... more >> Charite University Recruiting Berlin, Germany Contact: Linn K Kühl, PhD +49 30 450-517625 linn.kuehl@charite.de Collapse << |
NCT01536925 | - | - | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48201 Collapse << |
NCT00605904 | Alcoholism | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT02963181 | Hypotension, Orthostatic ... more >> Hypertension Autonomic Nervous System Diseases Collapse << | Early Phase 1 | Recruiting | August 2019 | Canada, Ontario ... more >> University Hospital Recruiting London, Ontario, Canada, N6A5A5 Contact: Kurt Kimpinski, MD 5196633337 kkimpin@uwo.ca Contact: Jacquie Baker, MSc 519-685-8500 ext 73140 jbaker62@uwo.ca Collapse << |
NCT00032838 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT03154567 | Marijuana Abuse | Phase 1 | Recruiting | December 2019 | United States, Michigan ... more >> Tolan Park Medical Building Recruiting Detroit, Michigan, United States, 48201 Contact: Leslie Lundahl, PhD Collapse << |
NCT00605904 | - | - | Completed | - | - |
NCT00535002 | Cocaine Related Disorders | Phase 2 | Completed | - | United States, South Carolina ... more >> Medical University of South Carolina-GCRC Charleston, South Carolina, United States, 29425 Collapse << |
NCT02578849 | - | - | Unknown | January 2016 | Denmark ... more >> Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital Recruiting Aarhus C, Denmark, 8000, Contact: Adjmal Nahimi, MD, PhD +4553639856 adjmalnahimi@gmail.com Contact: Albert Gjedde, MD, professor 29177601 ext 0045 gjedde@sund.ku.dk Collapse << |
NCT00814047 | Blood Flow Velocity ... more >> Autoregulation Ocular Physiology Collapse << | Phase 4 | Completed | - | Austria ... more >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 Collapse << |
NCT00042536 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00535002 | - | - | Completed | - | - |
NCT00217048 | Healthy Volunteers | Phase 1 Phase 2 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55902 Collapse << |
NCT01031979 | Post-Traumatic Stress Disorder | Phase 2 | Completed | - | United States, South Carolina ... more >> Ralph H. Johnson VA Medical Center, Charleston, SC Charleston, South Carolina, United States, 29401-5799 Collapse << |
NCT01031979 | - | - | Completed | - | - |
NCT00078715 | - | - | Completed | - | - |
NCT00975325 | Erectile Dysfunction | Phase 4 | Completed | - | Germany ... more >> SocraTec R&D GmbH Erfurt, Germany, D-99084 Collapse << |
NCT00078715 | Depression, Involutional ... more >> Major Depresssion Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT01593215 | Type 2 Diabetes | Phase 2 | Completed | - | Sweden ... more >> Skanes Universitetssjukhus Malmo, Skane, Sweden, 20502 Collapse << |
NCT00734422 | Phobic Disorders | Phase 2 Phase 3 | Completed | - | Netherlands ... more >> University of Amsterdam Amsterdam, Netherlands Collapse << |
NCT01593215 | - | - | Completed | - | - |
NCT00958880 | - | - | Completed | - | - |
NCT00958880 | Social Anxiety Disorder | Phase 3 | Completed | - | United States, Massachusetts ... more >> Boston University Boston, Massachusetts, United States, 02215 United States, Texas Southern Methodist University Dallas, Texas, United States, 75206 Collapse << |
NCT03520543 | Healthy Controls | Phase 1 | Not yet recruiting | January 21, 2019 | France ... more >> Service de Neurologie C - Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, GHE Not yet recruiting Bron, France, 69500 Contact: Chloe LAURENCIN, MD 04.72.11.80.22 chloe.laurencin@chu-lyon.fr Collapse << |
NCT00001329 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00748059 | Autonomic Nervous System Disea... more >>ses Orthostatic Hypotension Dopamine Beta-Hydroxylase Deficiency Orthostatic Intolerance Collapse << | Phase 1 | Active, not recruiting | December 2018 | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00004329 | - | - | Completed | - | United States, Texas ... more >> University of Texas Medical Branch Galveston, Texas, United States, 77555-0209 Collapse << |
NCT00223717 | Hypertension | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00000195 | Opioid-Related Disorders | Phase 2 | Withdrawn | - | United States, Connecticut ... more >> VA Connecticut Healthcare System New Haven, Connecticut, United States, 06519 Collapse << |
NCT00684840 | - | - | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48202 Collapse << |
NCT00103987 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00109642 | - | - | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT03015246 | Heroin Dependence ... more >> Opioid Use Disorder Collapse << | Phase 1 | Recruiting | December 2020 | United States, Kansas ... more >> Vince and Associates Recruiting Overland Park, Kansas, United States, 66212 Contact: Debra Kelsh, M.D. 913-696-1601 ext 6160 dkelsh@altasciences.com Principal Investigator: Mark Greenwald, PhD Principal Investigator: Debra Kelsh, M.D. Collapse << |
NCT00223691 | Autonomic Failure ... more >> Orthostatic Hypotension Collapse << | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
NCT00000196 | Opioid-Related Disorders | Phase 2 | Withdrawn | - | United States, Connecticut ... more >> VA Connecticut Healthcare System New Haven, Connecticut, United States, 06519 Collapse << |
NCT02243709 | Alcohol Use Disorders (AUD) | Phase 1 Phase 2 | Recruiting | December 2019 | United States, Rhode Island ... more >> Center for Alcohol and Addiction Studies, Brown University Recruiting Providence, Rhode Island, United States, 02912 Contact: Victoria Long, BS 401-863-6646 alcohol.stress.study@gmail.com Principal Investigator: Carolina L Haass-Koffler, PharmD Sub-Investigator: Robert M Swift, MD, PhD Collapse << |
NCT03670212 | Cigarette Smoking | Phase 1 | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48201 Collapse << |
NCT02007694 | Phobic Disorders | Phase 2 Phase 3 | Completed | - | Netherlands ... more >> University of Amsterdam Amsterdam, Nord Holland, Netherlands, 1018XA Collapse << |
NCT00709098 | Pulmonary Arterial Hypertensio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT00709956 | Pulmonary Arterial Hypertensio... more >>n Collapse << | Phase 3 | Completed | - | - |
NCT02541071 | Intrusive Memories | Not Applicable | Completed | - | Germany ... more >> Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Benjamin Franklin Berlin, Germany, 12203 Collapse << |
NCT01621620 | Pain | Not Applicable | Unknown | August 2014 | Israel ... more >> Tel Aviv Sourasky Medical Center, Pain Medicine Unit Not yet recruiting Tel Aviv, Israel Contact: Lior Dayan, M.D 972-50-4051014 Collapse << |
NCT00709098 | - | - | Completed | - | - |
NCT00032838 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00709956 | - | - | Completed | - | - |
NCT00605904 | - | - | Completed | - | - |
NCT00605904 | Alcoholism | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00029627 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT02963181 | Hypotension, Orthostatic ... more >> Hypertension Autonomic Nervous System Diseases Collapse << | Early Phase 1 | Recruiting | August 2019 | Canada, Ontario ... more >> University Hospital Recruiting London, Ontario, Canada, N6A5A5 Contact: Kurt Kimpinski, MD 5196633337 kkimpin@uwo.ca Contact: Jacquie Baker, MSc 519-685-8500 ext 73140 jbaker62@uwo.ca Collapse << |
NCT01536925 | - | - | Completed | - | United States, Michigan ... more >> Wayne State University Detroit, Michigan, United States, 48201 Collapse << |
NCT02470026 | Major Depressive Disorder ... more >> Early Life Trauma Collapse << | Not Applicable | Recruiting | October 2018 | Germany ... more >> Charite University Recruiting Berlin, Germany Contact: Linn K Kühl, PhD +49 30 450-517625 linn.kuehl@charite.de Collapse << |
NCT03154567 | Marijuana Abuse | Phase 1 | Recruiting | December 2019 | United States, Michigan ... more >> Tolan Park Medical Building Recruiting Detroit, Michigan, United States, 48201 Contact: Leslie Lundahl, PhD Collapse << |
NCT00535002 | Cocaine Related Disorders | Phase 2 | Completed | - | United States, South Carolina ... more >> Medical University of South Carolina-GCRC Charleston, South Carolina, United States, 29425 Collapse << |
NCT02578849 | - | - | Unknown | January 2016 | Denmark ... more >> Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital Recruiting Aarhus C, Denmark, 8000, Contact: Adjmal Nahimi, MD, PhD +4553639856 adjmalnahimi@gmail.com Contact: Albert Gjedde, MD, professor 29177601 ext 0045 gjedde@sund.ku.dk Collapse << |
NCT00042536 | - | - | Completed | - | United States, Maryland ... more >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 Collapse << |
NCT00535002 | - | - | Completed | - | - |
NCT01031979 | Post-Traumatic Stress Disorder | Phase 2 | Completed | - | United States, South Carolina ... more >> Ralph H. Johnson VA Medical Center, Charleston, SC Charleston, South Carolina, United States, 29401-5799 Collapse << |
NCT00734422 | Phobic Disorders | Phase 2 Phase 3 | Completed | - | Netherlands ... more >> University of Amsterdam Amsterdam, Netherlands Collapse << |
NCT00217048 | Healthy Volunteers | Phase 1 Phase 2 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55902 Collapse << |
NCT00078715 | Depression, Involutional ... more >> Major Depresssion Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00814047 | Blood Flow Velocity ... more >> Autoregulation Ocular Physiology Collapse << | Phase 4 | Completed | - | Austria ... more >> Department of Clinical Pharmacology, Medical University of Vienna Vienna, Austria, 1090 Collapse << |
NCT00958880 | - | - | Completed | - | - |
NCT01593215 | Type 2 Diabetes | Phase 2 | Completed | - | Sweden ... more >> Skanes Universitetssjukhus Malmo, Skane, Sweden, 20502 Collapse << |
NCT01031979 | - | - | Completed | - | - |
NCT00975325 | Erectile Dysfunction | Phase 4 | Completed | - | Germany ... more >> SocraTec R&D GmbH Erfurt, Germany, D-99084 Collapse << |
NCT00958880 | Social Anxiety Disorder | Phase 3 | Completed | - | United States, Massachusetts ... more >> Boston University Boston, Massachusetts, United States, 02215 United States, Texas Southern Methodist University Dallas, Texas, United States, 75206 Collapse << |
NCT01593215 | - | - | Completed | - | - |
NCT03520543 | Healthy Controls | Phase 1 | Not yet recruiting | January 21, 2019 | France ... more >> Service de Neurologie C - Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, GHE Not yet recruiting Bron, France, 69500 Contact: Chloe LAURENCIN, MD 04.72.11.80.22 chloe.laurencin@chu-lyon.fr Collapse << |
NCT00078715 | - | - | Completed | - | - |
靶点 | Description | IC50 |
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